TERTIARY STRUCTURE AND CONFORMATIONAL DYNAMICS OF THE ANTI-AMYLOIDOGENIC CHAPERONE DNAJB6B AT ATOMISTIC RESOLUTION

Tertiary structure and conformational dynamics of the anti-amyloidogenic chaperone DNAJB6b at atomistic resolution

Abstract DNAJB6b is a molecular chaperone of the heat shock protein network, shown to play a crucial role in preventing aggregation of several disease-related intrinsically disordered proteins.Using homology modeling and microsecond-long all-atom molecular dynamics (MD) simulations, we show that monomeric DNAJB6b is a transiently interconverting pr

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The risk of iatrogenic radial nerve and/or profunda brachii artery injury in anterolateral humeral plating using a 4.5 mm narrow DCP: A cadaveric study.

IntroductionFixation of humeral shaft fractures with a plate and screws can endanger the neurovascular structure if proper care is not taken.No studies to our knowledge have studied the risk of iatrogenic radial nerve and/or profunda brachii artery (RNPBA) injury from each screw hole of a 4.5 mm narrow dynamic compression plate (narrow DCP).The pur

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